Detection Of Pathological Protein Aggregation

  • Published: Sep 12, 2019
  • Earliest Priority: Mar 06 2018
  • Family: 2
  • Cited Works: 4
  • Cited by: 0
  • Cites: 4
  • Additional Info: Cited Works Full text

The present invention provides novel methods of identifying, monitoring or determining the risk of developing a protein misfolding neurodegenerative disorder in a subject, particularly an alpha synucleinopathy(including Parkinson's disease and dementia with Lewy bodies) using extracellular vesicle samples. Corresponding methods for selecting a treatment and assaying for the presence of a pathological prion-like protein (or one or more ceramide species) in an extracellular vesicle sample are also provided.


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