Poly(amine-co-disulfide Ester) Nanoparticles And Methods Of Use

  • Published: Dec 6, 2018
  • Earliest Priority: Jun 01 2017
  • Family: 1
  • Cited Works: 63
  • Cited by: 0
  • Cites: 1
  • Additional Info: Cited Works Full text
Abstract

Polymers, containing one or more poly(amine-co-disulfide ester) polymeric units, and polymeric nanoparticles formed therefrom, are provided. The nanoparticles possess dual pH-responsive and redox- responsive properties, giving rise to enhanced release of cargo in disease- relevant microenvironments. The nanoparticles also show selective uptake by diseased tissues, compared to healthy tissues. The polymers are synthesized via enzyme-catalyzed polymerization reactions. Also provided are pharmaceutical compositions including nanoparticles having an effective amount of chemotherapeutic agents for inhibit the growth of tumor tissue.


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