Poly(amine-co-disulfide Ester) Nanoparticles And Methods Of Use


Polymers, containing one or more poly(amine-co-disulfide ester) polymeric units, and polymeric nanoparticles formed therefrom, are provided. The nanoparticles possess dual pH-responsive and redox- responsive properties, giving rise to enhanced release of cargo in disease- relevant microenvironments. The nanoparticles also show selective uptake by diseased tissues, compared to healthy tissues. The polymers are synthesized via enzyme-catalyzed polymerization reactions. Also provided are pharmaceutical compositions including nanoparticles having an effective amount of chemotherapeutic agents for inhibit the growth of tumor tissue.


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