Methods For Phenotyping Of Intact Bones By Tissue Clearing And Staining

Abstract

In various embodiments, the present application teaches methods and kits for clearing and optionally subsequently visualizing tissue containing bone. In some embodiments, the method includes serially incubating cleared bone in refractive index matching solutions with progressively higher refractive indexes. In some embodiments, the methods teach immunolabeling and/or staining tissue containing bone and optionally visualizing the immunolabeled and/or stained tissue containing bone.


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Document History
  • Publication: May 12, 2016
  • Application: Nov 6, 2015
    WO US 2015/0059600 W
  • Priority: Nov 7, 2014
    US US 201462076705 P

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