Pharmaceutical Compositions Comprising A Gpg Oligodeoxynucleotide And Cyclic Di-gmp


The present invention relates to pharmaceutical compositions comprising an immunostimulatory amount of at least two immunopotentiators, wherein a first immunopotentiator is a non-methylated cytidyl guanosyl oligodeoxynucleotide (CpG ODN) and a second immunopotentiator is 3 ',5 '-cyclic diguanylic acid (c-di-GMP), and a pharmaceutically acceptable carrier. The invention also relates to the use of such pharmaceutical compositions for the induction of an immune response against tumor-specific antigens. Also the invention relates to their use in in situ tumor-destruction therapy and to such pharmaceutical compositions for use in the treatment of a mammal suffering from cancer.

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Document History
  • Publication: Dec 18, 2014
  • Application: Jun 13, 2014
    WO EP 2014062308 W
  • Priority: Jun 14, 2013
    EP EP 13172144 A

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