Methods For Screening Drugs For Reducing Cd28 Costimulation Of T Cells

Abstract

The present invention relates to methods for screening drugs for reducing CD28 costimulation of T cells in a subject in need thereof. In particular, the present invention relates to a method for screening a plurality of test substances useful for reducing CD28 costimulation of T cells in a subject in need thereof comprising the steps consisting of a1) testing each of the test substances for its ability to bind to a RLTR polypeptide and a2) positively selecting the test substances that are able to bind to the RLTR polypeptide.


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Document History
  • Publication: Oct 30, 2014
  • Application: Apr 18, 2014
    WO EP 2014058006 W
  • Priority: Apr 22, 2013
    EP EP 13305522 A

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