Polymyxins, Compositions, Methods Of Making And Methods Of Use

Abstract

Disclosed herein is a composition comprising at least one polymyxin or a salt thereof represented by formula (I) wherein R1 is an aliphatic linear or branched C6-C10 acyl group, or (I') R5 is -CH(CH3)2, -CH2CH(CH3)2, -CH(CH3)CH2CH3, or -CH2C6H5; R6 is -CH(CH3)2, -CH2CH(CH3)2, or -CH(CH3)CH2CH3; each of R2, R3, R4, R7and R8 is either -(CH2)XCH2NH2 or -(CH2)xCH2N(CH2SO3M)2; wherein x is 0 or 1; wherein M is a monovalent cation; and wherein at least three of R2, R3, R4, R7and R8 are -(CH2)xCH2N(CH2SO3M)2.


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Document History
  • Publication: Jul 17, 2014
  • Application: Jan 9, 2014
    WO EP 2014050320 W
  • Priority: Nov 15, 2013
    US US 201361904793 P
  • Priority: Jan 11, 2013
    US US 201361751341 P

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