Il-15r Alpha Forms, Cells Expressing Il-15r Alpha Forms, And Therapeutic Uses Of Il-15r Alpha And Il-15/il-15r Alpha Complexes

  • Published: Jul 3, 2014
  • Earliest Priority: Oct 24 2012
  • Family: 18
  • Cited Works: 1
  • Cited by: 0
  • Cites: 4
  • Sequences: 46
  • Additional Info: Full text Sequence
Abstract

In one aspect, described herein are cyclical administration regimens for the administration of complexes comprising interleukin-15 ("IL-15") covalently or noncovalently bound to IL-15 receptor alpha ("IL-15Ra") to patients in order to enhance IL-15-mediated immune function. In a specific aspect, the cyclical administration regimens are useful in the prevention, treatment, and/or management of disorders in which enhancing IL-15-mediated function is beneficial, such as cancer, infectious diseases, immune deficiencies and lymphopenia. Also described herein are purified soluble forms of IL-15Ra, cells that recombinantly express soluble forms ofiL-15Ra, and compositions comprising complexes of IL-15 covalently or non-covalently bound to soluble forms ofiL-15Ra. Further described herein are host cells that recombinantly express IL15-Ra derivatives comprising a mutation or deletion in the extracellular domain cleavage site, including IL-15Ra derivatives comprising the extracellular domain of IL-15Ra and a transmembrane domain of a heterologous molecule.


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Document History
  • Publication: Jul 3, 2014
  • Application: Oct 23, 2013
    WO US 2013/0066424 W
  • Priority: May 6, 2013
    US US 201361820035 P
  • Priority: Oct 24, 2012
    US US 201261718169 P

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