Doc Type: Patent Application
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Abstract

The present invention provides an improved processes having practical utility for preparing 2-oxindoles of formula I comprising preparation of 2-nitroarylmalonate diester of formula II as first intermediate and subsequent insitu reductive cyclisation using metal acid combination and its modified work-up to form compound of formula I free from metal generated impurity of formula M(OH)X wherein M is metal cation and X is anion. R is selected from hydrogen, linear, branched or cyclic alkyl, aryl, substituted aryl, heteroaryl, haloalkyl like CF3, alkoxy, haloalkoxy, thioalkyl and halogen preferably chloro Formula I wherein R' and R" are same or different and is selected from linear.branched and cyclic alkyl (C1C4groups)preferably methyl R is selected from hydrogen, linear, branched or cyclic alkyl, aryl, substituted aryl, heteroaryl, haloalkyl like CF3, alkoxy, haloalkoxy, thioalkyl and halogen preferably chloro Formula II.


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Document History
  • Publication: Jun 27, 2013
  • Application: Feb 29, 2012
    WO IN 2012000137 W
  • Priority: Dec 20, 2011
    IN IN 3577MU2011 A

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