Modified Toll-like Receptor 2 (tlr2) Ligands As Inhibitors Of Neutrophil Recruitment

Abstract

The present invention provides modified TLR2 ligands useful for modulating inflammatory responses. In particular, the ligands comprise (a) a fatty acid di- or tri-linoleate and (b) a GMl -binding peptide. The linoleate provides the anti-inflammtory function, while the GMl -binding peptide facilitates endocytosis.


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Document History
  • Publication: Mar 7, 2013
  • Application: Aug 30, 2012
    WO IB 2012002208 W
  • Priority: Aug 30, 2011
    US US 201161529044 P

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