Generation Of Mesodermal Cells From Pluripotent Stem Cells


The invention relates to in vitro methods for producing mesodermal cells, more particularly cardiac cells, even more particularly cardiomyocytes, from mammalian pluripotent stem (mPS) cells using Eomes in conditions in which Activin signalling is substantially absent. The invention further encompasses so-obtained mesodermal or cardiac cells; cell populations comprising these cells; compositions comprising the mesodermal or cardiac cells or the cell populations; and downstream uses thereof, for example, for medicinal applications such as cell therapy, drug screening or research purposes.

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Document History
  • Publication: Jan 24, 2013
  • Application: Jul 13, 2012
    WO EP 2012063853 W
  • Priority: Jul 15, 2011
    EP EP 11174231 A

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