Recombinant Proteins With A Selective Inactivation Activity On Target Proteins

Abstract

The present invention refers to a recombinant protein comprising a target-specific recognition domain and a degradation-inducing domain,said protein having a selective inactivation activity on target proteins, a genetic construct encoding the above protein, a vector and cell line comprising said genetic construct. The invention also refers to the above protein or genetic construct for use as a medicament, in particular for the treatment of any type of disease, where degradation of a defined secretory or membrane bound protein is required in order to ameliorate or cure the disease, more in particular said disease is a neurodegenerative disorder, a tumour, a genetic disease, a hypersensitivity disorder, a bacterial, parasitic or viral infection. The invention further refers to a pharmaceutical composition comprising said genetic construct and to the use of the above protein or of the genetic construct for the selective inactivation of target proteins.


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Document History
  • Publication: May 31, 2012
  • Application: Nov 24, 2011
    WO IB 2011055274 W
  • Priority: Nov 25, 2010
    IT IT PD20100356 A

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