Combination Of Braf And Vegf Inhibitors

  • Published: Mar 22, 2012
  • Earliest Priority: Sep 14 2010
  • Family: 9
  • Cited Works: 91
  • Cited by: 4
  • Cites: 6
  • Additional Info: Cited Works Full text

A novel combination comprising the VEGFR inhibitor 5-[[4-[(2,3-dimethyl-2H- indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methylbenzenesulfonamide, or a pharmaceutically acceptable salt thereof, with a B-Raf inhibitor, particularly N-{3-[5- (2-Amino-4-pyrimidinyl)-2-(1,1 -dimethylethyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6- difluorobenzenesulfonamide or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising the same and methods of using such combinations and compositions in the treatment of conditions in which the inhibition of VEGFR and/or B-Raf is beneficial.

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Document History
  • Publication: Mar 22, 2012
  • Application: Sep 2, 2011
    WO US 2011/0050302 W
  • Priority: Sep 14, 2010
    US US 38251110 P

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