Substituted Heteroarylpiperidine Derivatives As Melanocortin-4 Receptor Modulators


The present invention relates to substituted heteroarylpiperidine derivatives as melanocortin-4 receptor modulators, in particular as melanocortin 4 receptor antagonists. The antagonists are useful for the treatment of disorders and diseases such as cachexia induced by e.g. cancer, chronic kidney disease (CKD) or chronic heart failure (CHF), muscle wasting, anorexia induced by e.g. chemotherapy or radiotherapy, anorexia nervosa, amyotrophic lateral sclerosis (ALS), pain, neuropathic pain, anxiety and depression, nausea and emesis.

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Document History
  • Publication: Jul 22, 2010
  • Application: Jan 11, 2010
    WO EP 2010000091 W
  • Priority: Jan 14, 2009
    US US 14448509 P
  • Priority: Jan 14, 2009
    EP EP 09000437 A

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