Keloid Derived Precursor Cells And Its Applications Of Use Thereof

Abstract

The present invention relates to keloid derived precursor cells (KPCs), which exhibit clonogenicity, self-renewal, distinct embryonic and mesenchymal stem cell surface markers, and multipotent differentiation. More specifically, the invention provides methods of utilizing KPCs for the generation of a human keloid-like tumor model, which allows for testing of the anti-tumor therapeutic effect of antibodies targeting distinct niche components, such as IL-6 and IL-17.


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Document History
  • Publication: Jul 15, 2010
  • Application: Jan 12, 2010
    WO US 2010/0020774 W
  • Priority: Sep 4, 2009
    US US 24014109 P
  • Priority: Jan 12, 2009
    US US 14409109 P

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