Dna Methylomes

Abstract

Methods and kits for diagnosing and/or monitoring the progression of or otherwise staging a disease caused by an infection by a double stranded DNA virus in a test sample obtained from a subject comprise determining the methylation status of the viral genome. The presence of hypermethylation of the viral genome indicates a positive diagnosis of the disease and/or an increased level of methylation of the viral genome indicates the progression of the disease to a more advanced form. Relevant viruses includes, HPV18, HBV and EBV. Suitable diseases linked to viral infection include cancers such as anogenital, hepatic and nasopharyngeal cancers and lymphomas. The methylomes of HPV16, HPV18, EBV and HBV are provided.


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