Methods For Inhibiting Six 1 And Eya Proteins

Abstract

In some aspects, the invention provides a method of inhibiting interaction of Sixl with Eya2 comprising contacting a cell expressing Sixl and Eya2 with an agent that inhibits binding of Sixl to Eya2 or an agent that inhibits the phostphatase activity of Eya2 on Sixl. In other apsects, the invention provides a method of treating cancer in a subject comprising administering to said subject an effective amount of an agent that inhibits Sixl interaction with Eya2 or an agent that inhibits the phostphatase activity of Eya2 on Sixl. In some embodiments, the invention further provides for the administration of a second cancer therapy to the patient. In still further aspects, the invention provides a method of identifying a candidate anti-cancer agent. The candidate inhibitor may be a nucleic acid, a protein, a peptide or a small molecule.


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Document History
  • Publication: Dec 10, 2009
  • Application: Feb 25, 2009
    WO US 2009/0035150 W
  • Priority: Feb 25, 2008
    US US 3129708 P

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