Methods For N-demethylation Of Morphine And Tropane Alkaloids


The present invention relates to a method for N -demethylation of a tertiary N-methylated heterocycle, particularly a morphine or tropane alkaloids or derivatives thereof. The method, comprises reacting said tertiary N-methylated heterocycle with a metal catalyst, for example Pd(OAc)2 or Cu(OAc)2 in the presence of an oxidizing agent such as oxygen or ammonium persulfate.

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Document History
  • Publication: Jan 8, 2009
  • Application: Jun 30, 2008
    WO CA 2008001179 W
  • Priority: Jun 29, 2007
    US US 77122707 A

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