Trp/his Exchange And Kynurenine Induced Trp Transport

  • Published: Sep 12, 2008
  • Earliest Priority: Mar 01 2007
  • Family: 5
  • Cited Works: 0
  • Cited by: 1
  • Cites: 1
  • Additional Info: Full text Published
Abstract

The present invention provides methods for detecting changes in tryptophan concentrations in a cell and methods for identifying agents that modulate cellular tryptophan concentrations. In particular, the present invention provides methods for detecting cellular exchange between tryptophan and kynurenine, and methods for identifying agents that modulate this exchange. The present invention also provides methods for treating a disease associated with immunosuppression in a subject in need thereof. In particular,. the present invention is directed toward a method of treating a disease associated with immunosuppression comprising contacting the disease with an agent that modulates cellular Trp/kynurenine exchange. Furthermore, the present invention provides methods for identifying an agent that modulates an immunosuppression.


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