Diagnosis Of Collagen Ix Destruction

Abstract

A method for detecting or monitoring the presence of protein fragments, cleaved at novel cleaving sites near the N-terminal part of the collagen IX alpha 1 chain, close to the C-terminal part of the NC4 domain, and at the COL3 domain close to the NC3 domain. Neoepitope antibodies against the neoepitopes were created by the cleavages and an epitope in the cleaved N-terminal part of the NC4 domain unique to collagen IX. A diagnostic kit and antibodies useful in carrying out such methods are also presented.


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Document History
  • Publication: Sep 12, 2008
  • Application: Feb 29, 2008
    WO SE 2008050227 W
  • Priority: Feb 26, 2008
    US US 7242808 A
  • Priority: Mar 2, 2007
    US US 90468407 P

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