Polymorphism In The Slc30a8 Gene

  • Published: Mar 19, 2009
  • Earliest Priority: Feb 09 2007
  • Family: 2
  • Cited Works: 4
  • Cited by: 0
  • Cites: 2
  • Additional Info: Cited Works Full text

The present invention relates to a single nucleotide polymorphisme (SNP) identified in the slc30a8 gene, leading to a specific amino acid sequence of the coded protein, associated with susceptibility to diabetes. The invention is also relative to a transgenic mammalian model comprising a protein encoded bythe slc30a8 gene, having a specific polypeptidic sequence, which can be useful for elucidating the onset mechanism of diabetes, and for the screening of therapeutically active drugs for the treatment of diabetes, especially type II diabetes, and metabolic disorders, including syndrome X and obesity. The mammalian animal considered can be a mouse (preferably), a rat, a dog, a macaque, a chimp or a pig.


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Document History
  • Publication: Mar 19, 2009
  • Application: Feb 8, 2008
    WO EP 2008051577 W
  • Priority: Feb 9, 2007
    US US 90043307 P

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