Method And Apparatus For Making Uniformly Sized Particles

  • Published: Jul 24, 2008
  • Earliest Priority: Jan 12 2007
  • Family: 5
  • Cited Works: 0
  • Cited by: 0
  • Cites: 0
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A method and apparatus for making substantially uniformly sized liposomes and other small particles are provided. Droplets of a first liquid are ejected into a laminar flow of a second liquid, each droplet having a volume of from 0.97V to 1.03 V, where V is the mean droplet volume and 1pL = V = 5OpL, wherein the first and second liquids are no more than sparingly soluble in one another, and wherein the first liquid contains a solute dissolved, dispersed, or suspended therein; and the first liquid is then removed to form a plurality of substantially uniformly sized particles. In one embodiment, the apparatus includes liquid inlet and outlet channels, a plurality of transverse liquid channels extending from the liquid inlet to the liquid outlet channel, a plurality of nozzles in liquid flow communication with the plurality of transverse liquid channels, one or more nozzle actuators coupled to the plurality of nozzles, and an evaporator coupled to the liquid outlet channel.

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Document History
  • Publication: Jul 24, 2008
  • Application: Jan 12, 2008
    WO US 2008/0050946 W
  • Priority: Jan 12, 2007
    US US 65361807 A

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