Pancreatic B-cells Expressing Abca1 And Uses Thereof


Methods for identifying ATP-binding cassette A1 (ABCA1) agonists using pancreatic B-cells capable of expressing ABCA1 are disclosed. Methods for increasing the expression of ABCA 1 in pancreatic B cells by providing an expression vector comprising pancreatic B-cell control sequences and a nucleic acid encoding ABCA1 are also disclosed. Pancreatic B-cells which express ABCA1 and agonists of ABCA 1 which modulate pancreatic B-cell function are used in treating and preventing the onset of type 2 diabetes mellitus.

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Document History
  • Publication: Nov 29, 2007
  • Application: May 23, 2007
    WO CA 2007000926 W
  • Priority: May 23, 2006
    US US 80251306 P

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