Abstract

The present invention includes a method of measuring cytolytic activity including providing a device capable of monitoring cell-substrate impedance operably connected to an impedance analyzer, adding target cells to at least one well of the device, adding effector cells to the at least one well, monitoring impedance of the at least one well and optionally determining a cell index from the impedance, wherein monitoring impedance includes measuring impedance during at least one time point before and at least one time point after adding effector cells, and determining viability of said target cells after adding effector cells by comparing the impedance or optionally the cell index at the at least one time point after adding effector cells to the impedance or optionally the cell index at the at least one time point before adding effector cells.


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Document History
  • Publication: Feb 9, 2006
  • Application: Aug 4, 2005
    WO US 2005/0027891 W
  • Priority: Jun 10, 2005
    US US 68942205 P
  • Priority: Mar 10, 2005
    US US 66089805 P
  • Priority: Mar 10, 2005
    US US 66082905 P
  • Priority: Feb 9, 2005
    US US 5563905 A
  • Priority: Jan 26, 2005
    US US 64707505 P
  • Priority: Jan 26, 2005
    US US 64718905 P
  • Priority: Nov 22, 2004
    US US 63007104 P
  • Priority: Nov 12, 2004
    US US 98773204 A
  • Priority: Sep 27, 2004
    US US 61387204 P
  • Priority: Aug 4, 2004
    US US 59860904 P
  • Priority: Aug 4, 2004
    US US 59860804 P

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