Abstract

2-Phenyl substituted benzimidazoles and imidazo[4,51pyridines of formula (I)are disclosed as inhibitors of Cds1 and useful as adjuvants to chemotherapy or radiation therapy in the treatment of cancer. Wherein W is -COOH, -(CO)NH2, or -(SO2)NH2; Q is N or CH; Z is selected from the group consisting of a) >C=O, >C=CHRf, >CRdRd, >CF2, >CRdORe, >C(ORd)ORe, b) >C(Rd)NRdRg, C) -SO2NRdC(Rh)2-, where A is fuse d at the b or c faces, at a face of A which contains two carbon atoms, which is saturated or unsaturated, where A is fused at the b or c; faces, at a face of A which contains two carbon atoms, which is saturated or unsaturated, d) >NC1-4alkyl, where the alkyl is optionally substituted with a. substituent selected from the group consisting of -NH2, -NHC1-4alkyl, -N(C1-4aIkyl)2, -CONH2, -CONHC1-4alkyl-, -CON(C1-4aIkyl)2, -COOH, --COOC1-4alkyl, -OH and -OC1-4alkyl; A is selected from the group consisting of: a) phenyl or other substituents defined in claim1. The other substituents are as defined in claim1.


Claims

Download Citation


Sign in to the Lens

Feedback