Induction Of Ctla-4 Upregulation In T Lymphocytes


There is disclosed a method of inducing CTLA-4 up-regulation in a T lymphocyte, comprising contacting a T lymphocyte with a compound selected from the group consisting of cyclic AMP, CAMP inducers, cAMP analogs, phosphodiesterase inhibitors and Ca <2+> inducers. The method may be used to induce CTLA-4 upregulation both in resting and activated T lymphocytes. A T lymphocyte obtainable by the method of the invention is also disclosed.


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Document History
  • Publication: May 21, 2004
  • Application: Nov 5, 2003
    WO EP 0312332 W
  • Priority: Nov 6, 2002
    IT IT TO20020954 A

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