Transgenic Mouse With Disrupted Calcium Ion Channel Alpha1b Gene And Production Method Thereof


The disclosure concerns knockout mice of disrupting alpha 1B subunit of N-type calcium channel by gene targeting, showing reduced response to mechanical and radiant heat stimuli, production method thereof, and a method for reducing pain by suppressing the function of alpha 1B protein of N-type calcium channel. In addition, alpha 1B knockout mice of the present invention have not N-type channel activity and are useful to screening regulator of pain related to N-type calcium channel.

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Document History
  • Publication: Jul 24, 2003
  • Application: Jan 15, 2002
    WO KR 0200064 W
  • Priority: Jan 15, 2002
    KR KR 0200064 W

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