Modulators For Sirt5 And Assays For Screening Same

Abstract

Sirt5, a mitochondrial Sirtuin, has been identified herein as an efficient demalonylase and desuccinylase. Disclosed herein are assays to identify Sirt5 modulators based on this robust enzymatic activity. Sirt5-specific modulators can be used study the biological function of Sirt5 and to target Sirt5 activities in treating human diseases.


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Document History
  • Publication: Apr 3, 2018
  • Application: Jul 7, 2011
    US US 201113808706 A
  • Priority: Jul 7, 2011
    US US 201113808706 A
  • Priority: Jul 7, 2011
    US US 2011/0043130 W
  • Priority: Jul 7, 2010
    US US 36207810 P

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