US 9907770 B2 - Methods And Compositions For Increasing The Anaerobic Working Capacity In Tissues - The Lens - Free & Open Patent and Scholarly Search

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US 9907770 B2

Methods And Compositions For Increasing The Anaerobic Working Capacity In Tissues

Published: Mar 6, 2018
Family: 23
Cited Works: 424
Cited by: 0
Cites: 65
Additional Info: Cited Works Full text

Abstract

Provided are compositions comprising beta-alanylhistidine peptides and/or beta-alanines, and methods for administering these peptides and amino acids. In one aspect, the compositions and methods cause an increase in the blood plasma concentrations of beta-alanine and/or creatine.

Claims

An improved method of delaying the onset of muscle fatigue in a human supplementing in a 24 hour period over a period of time with a human dietary supplement comprising beta-alanine that is not part of a dipeptide, oligopeptide or polypeptide in an amount sufficient to increase beta-alanylhistidine synthesis in the muscle, wherein the improved method comprises:
i) increasing the amount of beta-alanine in the dietary supplement ingested in a 24 hour period for a period of time,
wherein an increased amount is provided at a first increased amount for a first period of time and then is provided at a second increased amount for a second period of time, and wherein the ingested amount in the 24 hour period is ingested in one serving in the 24 hour period or in multiple servings at different times during the 24 hour period, and wherein the period of time includes more than two 24 hour periods, and

ii) decreasing the amount of beta-alanine ingested in a 24 hour period for a period of time following increasing the amount of beta-alanine ingested in a 24 hour period for a period of time.
The method of claim 1, wherein decreasing the amount of the amount of beta-alanine ingested is decreased daily.
The method of claim 1, wherein decreasing the amount of the amount of beta-alanine ingested is decreased every other day.
The method of claim 1, wherein decreasing the amount of the amount of beta-alanine ingested is decreased weekly.
The method of claim 1, wherein decreasing the amount of the amount of beta-alanine ingested is decreased every other week.
The method of claim 1, wherein decreasing the amount of the amount of beta-alanine ingested is decreased every day that the human participates in physical activity.
The method of claim 1, wherein decreasing the amount of the amount of beta-alanine ingested is decreased in 0.1 g increments.
The method of claim 1, wherein decreasing the amount of the amount of beta-alanine ingested is decreased in 0.2 g increments.
The method of claim 1, wherein decreasing the amount of the amount of beta-alanine ingested is decreased in 0.3 g increments.
The method of claim 1, wherein decreasing the amount of the amount of beta-alanine ingested is decreased in 0.4 g increments.
The method of claim 1, wherein decreasing the amount of the amount of beta-alanine ingested is decreased in 0.5 g increments.
The method of claim 1, wherein decreasing the amount of the amount of beta-alanine ingested is decreased in 0.6 g increments.
The method of claim 1, wherein decreasing the amount of the amount of beta-alanine ingested is decreased in 0.7 g increments.
The method of claim 1, wherein decreasing the amount of the amount of beta-alanine ingested is decreased in 0.8 g increments.
The method of claim 1, wherein decreasing the amount of the amount of beta-alanine ingested is decreased in 0.9 g increments.
The method of claim 1, wherein decreasing the amount of the amount of beta-alanine ingested is decreased in 1.0 g increments.
The method of claim 1, wherein decreasing the amount of the amount of beta-alanine ingested is decreased to a minimum of 1.0 g.
The method of claim 1, wherein decreasing the amount of beta-alanine ingested in a 24 hour period for a period of time is from 3 days to 8 weeks.
The method of claim 18, where decreasing the amount of beta-alanine ingested in a 24 hour period for a period of time is from 5 days to 6 weeks.
The method of claim 19, wherein decreasing the amount of beta-alanine ingested in a 24 hour period for a period of time is from 1 week to 4 weeks.
The method of claim 1, wherein the improvement further comprises increasing the amount of beta-alanine ingested in a 24 hour period for a period of time following decreasing the amount of beta-alanine ingested in a 24 hour period.
The method of claim 1, wherein the amount of beta-alanine ingested is increased daily.
The method of claim 1, wherein the amount of beta-alanine ingested is increased every other day.
The method of claim 1, wherein the amount of beta-alanine ingested is increased weekly.
The method of claim 1, wherein the amount of beta-alanine ingested is increased every other week.
The method of claim 1, wherein the amount of beta-alanine ingested is increased every day that the human participates in physical activity.
The method of claim 1, wherein the amount of beta-alanine ingested is increased in 0.1 g increments.
The method of claim 1, wherein the amount of beta-alanine ingested is increased in 0.2 g increments.
The method of claim 1, wherein the amount of beta-alanine ingested is increased in 0.3 g increments.
The method of claim 1, wherein the amount of beta-alanine ingested is increased in 0.4 g increments.
The method of claim 1, wherein the amount of beta-alanine ingested is increased in 0.5 g increments.
The method of claim 1, wherein the amount of beta-alanine ingested is increased in 0.6 g increments.
The method of claim 1, wherein the amount of beta-alanine ingested is increased in 0.7 g increments.
The method of claim 1, wherein the amount of beta-alanine ingested is increased in 0.8 g increments.
The method of claim 1, wherein the amount of beta-alanine ingested is increased in 0.9 g increments.
The method of claim 1, wherein the amount of beta-alanine ingested is increased in 1.0 g increments.
The method of claim 1, wherein the amount of beta-alanine ingested is increased to a maximum of 16 g.
The method of claim 1, wherein the period of time is from 3 days to 8 weeks.
The method of claim 38, where the period of time is from 5 days to 6 weeks.
The method of claim 39, wherein the period of time is from 1 week to 4 weeks.
The method of claim 1, wherein the improvement further comprises ingesting an amount of L-histidine to prevent loss of muscle histidine.
The method of claim 41, wherein the amount of L-histidine is 0.1 g to 16 g.

Owners (US)

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Applicants

Natural Alternatives Int Inc
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Inventors

Harris Roger
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Dunnett Mark
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CPC Classifications

A23L33/175
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A23P10/40
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IPC Classifications

A61K31/155
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Document History

Publication: Mar 6, 2018
US 9907770 B2
Application: Mar 31, 2017
US 201715476620 A
Priority: Mar 31, 2017
US 201715476620 A
Priority: Mar 30, 2015
US 201514673556 A
Priority: May 22, 2013
US 201313900244 A
Priority: Jan 23, 2012
US 201213356182 A
Priority: Aug 10, 2010
US 80635610 A
Priority: Aug 29, 2008
US 23124008 A
Priority: Nov 18, 2003
US 71721703 A
Priority: Apr 10, 2003
US 46223803 P