High Efficiency Reprogramming Of Fibroblasts Into Cardiomyocytes

Abstract

Pro-fibrotic signaling potently antagonizes cardiac reprogramming. Inhibition of pro-fibrotic signaling using small molecules that target the transforming growth factor-β/SMAD, or Rho kinase leads to conversion of approximately 60% of fibroblasts into beating cardiomyocytes. Conversely, over-activation of these pro-fibrotic signaling networks inhibits cardiac reprogramming. Using the disclosed methods, fibroblasts are converted to spontaneously contracting cardiomyocytes in less than two weeks.


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Document History
  • Publication: Feb 6, 2018
  • Application: Mar 16, 2016
    US US 201615072122 A
  • Priority: Mar 16, 2016
    US US 201615072122 A
  • Priority: Mar 16, 2015
    US US 201562133716 P

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