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Locked Nucleic Acid Inhibitor Of Mir-145 And Uses Thereof

Abstract

The present invention provides oligonucleotides with chemical motifs that are miR-145 inhibitors. The oligonucleotides can be used for the treatment and prevention of a condition by inhibiting the expression or activity of miR-145 in cells of a subject in need thereof. Methods provided include treating or preventing pulmonary arterial hypertension, neointima formation, restenosis or hypertension in a subject in need thereof by administering to the subject an inhibitor of miR-145 expression or activity. Pharmaceutical compositions and kits comprising miR-145 inhibitors are also disclosed.


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Document History
  • Publication: Sep 5, 2017
  • Application: Mar 13, 2014
    US US 201414777172 A
  • Priority: Mar 13, 2014
    US US 201414777172 A
  • Priority: Mar 13, 2014
    US US 2014/0026538 W
  • Priority: Mar 15, 2013
    US US 201361800755 P

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