Methods For Treating Cancer By Administration Of Nucleic Acids Encoding Fap And Cancer Antigens

Abstract

A immunogenic composition is provided for use in methods for treating or preventing the development of a cancer, comprising a nucleic acid sequence encoding a cancer antigen and a nucleic acid sequence encoding fibroblast activation protein (FAP). In one embodiment, the composition comprises a vector comprising a first expression cassette comprising a nucleic acid sequence encoding an antigen of a, operatively linked to an expression control sequence that directs the expression of the antigen in a mammalian host cell. The composition further contains a vector comprising a second expression cassette comprising a nucleic acid sequence encoding fibroblast activation protein (FAP) operatively linked to an expression control sequence directing the expression of FAP in a mammalian host cell. In one embodiment, the cancer is one in which tumor progression depends on the fibroblasts expressing fibroblast activation protein (FAP).


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Document History
  • Publication: Aug 29, 2017
  • Application: Jun 23, 2016
    US US 201615190794 A
  • Priority: Jun 23, 2016
    US US 201615190794 A
  • Priority: Mar 14, 2014
    US US 201414212099 A
  • Priority: Mar 14, 2013
    US US 201361781429 P

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