{"search_session":{},"preferences":{"l":"es","queryLanguage":"es"},"patentId":"US_9650678_B2","frontPageModel":{"patentViewModel":{"ref":{"entityRefId":"088-847-080-376-426","entityRefType":"PATENT"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":8906,"type":"PATENT","title":"Univ Pennsylvania Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":24238,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8221,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search applicants and owners= \"Univ Pennsylvania\", \"Pennsylvania Univ\", \"Univ Penns*\", \"Penn* Univ\", \"University of Pennsylvania\", \"Pennsylvania University\".
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Search applicants and owners= \"Univ Pennsylvania\", \"Pennsylvania Univ\", \"Univ Penns*\", \"Penn* Univ\", \"University of Pennsylvania\", \"Pennsylvania University\".
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genotyping a cancer patient using a whole genome or locus specific method to determine at least one copy of SNP rs2232228 (G>A) within an HAS3 gene, and optimally administering a therapeutically effective dose of the anthracycline to the patient, wherein the therapeutically effective dose comprises a cumulative dose of approximately 1-250 mg/m2."],"number":1,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein the therapeutically effective dose comprises a cumulative dosage of approximately 1-150 mg/m2 when the cancer patient carries two copies of the SNP rs2232228(G>A)."],"number":2,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein the anthracycline is doxorubicin, daunomycin, epirubicin, mitoxantrone, valrubicin, or idarubicin."],"number":3,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein the anthracycline is administered in combination with one or more additional chemotherapeutics or cardioprotectants."],"number":4,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein the cardiotoxicity prevented is cardiomyopathy or congestive heart failure (CHF)."],"number":5,"annotation":false,"claim":true,"title":false},{"lines":["A method of preventing anthracycline-induced cardiomyopathy in a cancer patient comprising:\n
genotyping a cancer patient using a whole genome or locus specific method to determine at least one copy of SNP rs2232228 (G>A) within an HAS3 gene, and optimally administering a therapeutically effective dose of an anthracycline to the patient, wherein the therapeutically effective dose is a low or moderate dose."],"number":6,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 6, wherein the patient has one copy of the SNP rs2232228(G>A) and the effective dose is a cumulative dosage of approximately 1-250 mg/m2."],"number":7,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 6, wherein the patient has two copies of the SNP rs2232228(G>A) and the effective dose is a cumulative dosage of approximately 1-150 mg/m2."],"number":8,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 6, wherein the anthracycline is doxorubicin, daunomycin, epirubicin, mitoxantrone, valrubicin, or idarubicin."],"number":9,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 6, wherein the anthracycline is administered in combination with one or more additional chemotherapeutics or cardioprotectants."],"number":10,"annotation":false,"claim":true,"title":false}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}