Delivery Of Therapeutic Agents By A Collagen Binding Protein

Abstract

Methods of delivering therapeutic agents by administering compositions including a bacterial collagen-binding polypeptide segment linked to the therapeutic agent to subjects in need of treatment with the therapeutic agent are provided. In these methods, the therapeutic agent is not a PTH/PTHrP receptor agonist or antagonist, basic fibroblast growth factor (bFGF) or epidermal growth factor (EGF). The bacterial collagen-binding polypeptide segment delivers the agent to sites of partially untwisted or under-twisted collagen. Methods of treating collagenopathies using a composition including a collagen-binding polypeptide and a PTH/PTHrP receptor agonist are also provided. In addition, methods of treating hyperparathyroidism, and hair loss using compositions comprising a collagen binding polypeptide and a PTH/PTHrP receptor agonist are provided. Finally, methods of reducing hair regrowth by administering a composition including a collagen binding polypeptide and a PTH/PTHrP receptor antagonist are provided.


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Document History
  • Publication: Feb 28, 2017
  • Application: Dec 14, 2012
    US US 201214365226 A
  • Priority: Dec 14, 2012
    US US 201214365226 A
  • Priority: Dec 14, 2012
    US US 2012/0069831 W
  • Priority: Feb 9, 2012
    US US 201261596869 P
  • Priority: Dec 14, 2011
    US US 201161570620 P

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