{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"US_9549928_B2","frontPageModel":{"patentViewModel":{"ref":{"entityRefType":"PATENT","entityRefId":"137-039-414-463-686"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":8838,"type":"PATENT","title":"Univ of Illinois Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":10245,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8209,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search Applicants and Owners separately = \"Univ Illinois\", \"Illinois Univ\", \"University of Illinois\", \"Illinois University\", \"University Illinois NOT Northern NOT southern NOT State\".
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Total patents: 9630
Search Applicants and Owners separately: uni* illinois chicago
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Search Applicants and Owners separately = \"Univ Illinois\", \"Illinois Univ\", \"University of Illinois\", \"Illinois University\", \"University Illinois NOT Northern NOT southern NOT State\".
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Total patents: 9630
Search Applicants and Owners separately: uni* illinois chicago
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administering to the subject a composition that includes a therapeutically effective amount of at least one M1 agonist compound without substantially producing M2, M3, M4 and/or M5 subtype receptor agonist activity;\n
wherein the M1 agonist compound is [5-(3-ethyl-1,2,4-oxadiazol-5-yl)-1,4,5,6-tetrahydropyrimidine] (CDD-0102), or a pharmaceutically acceptable salt or hydrate thereof; and\n
wherein the subject does not have a cholinergic deficit, and does have cognitive deficits not associated with a neurodegenerative disorder; and,\n
improving the cognitive flexibility function in the subject."],"number":1,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the CDD-0102 compound, or a pharmaceutically acceptable salt or hydrate thereof, is administered to the subject in a dose of\n
about 0.01 mg/kg to about 0.3 mg/kg."],"number":2,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 2, wherein the CDD-0102 compound or a pharmaceutically acceptable salt or hydrate thereof, is administered to the subject in a dose between about 0.01 mg/kg and about 0.3 mg/kg, to thereby effect improved behavioral flexibility in the subject."],"number":3,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the CDD-0102 compound, or a pharmaceutically acceptable salt or hydrate thereof, is administered to the subject in at least one member selected from the group consisting of a single daily dose, multiple daily doses, two daily doses, three daily doses, four daily doses and five daily doses."],"number":4,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim wherein the CDD-0102 compound, or a pharmaceutically acceptable salt or hydrate thereof, is orally administered to the subject."],"number":5,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the subject has one or more neuropsychiatric diseases selected from: dysexecutive syndrome of schizophrenia; Fragile X disease; chronic alcoholism; traumatic brain injury; autism spectrum disorders; attention-deficit hyperactivity disorders; and post-traumatic stress disorder."],"number":6,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the subject is a human child."],"number":7,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the subject is a human adult."],"number":8,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the compound is formulated in a nutraceutical composition and is administered orally."],"number":9,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the administration is chronic."],"number":10,"annotation":false,"title":false,"claim":true}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}