Global Proteomic Screening Of Random Bead Arrays Using Mass Spectrometry Imaging


Methods for proteomic screening on random protein-bead arrays by mass spec is described. Photocleavable mass tags are utilized to code a protein library (bait molecules) displayed on beads randomly arrayed in an array substrate. A library of probes (prey) can be mixed with the protein-bead array to query the array. Because mass spec can detect multiple mass tags, it is possible to rapidly identify all of the interactions resulting from this mixing.

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Document History
  • Publication: Dec 6, 2016
  • Application: Dec 17, 2013
    US US 201314108641 A
  • Priority: Dec 17, 2013
    US US 201314108641 A
  • Priority: Jun 29, 2011
    US US 201113172164 A
  • Priority: Jun 30, 2010
    US US 35996410 P

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