Genetically Modified Mouse With An Inducible Acvr1 Gene With A Mutant R206h Exon 5 That Has Ectopic Bone Formation

Abstract

A genetically modified mouse is provided that comprises a conditional Acvr1 allele that comprises a mutated exon that, upon induction, converts to a mutant exon phenotype, wherein the mutant exon phenotype includes ectopic bone formation. Mice comprising a mutant Acvr1 exon 5 in antisense orientation, flanked by site-specific recombinase recognition sites, are provided, wherein the mice further comprise a site-specific recombinase that recognizes the site-specific recombinase recognitions sites, wherein the recombinase is induced upon exposure of the mouse to tamoxifen. Upon exposure to tamoxifen, the recombinase is expressed and acts on the RRS-flanked mutant exon 5 and places the mutant exon 5 in sense orientation and deletes the wild-type exon.


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Document History
  • Publication: Dec 6, 2016
  • Application: Mar 12, 2014
    US US 201414207320 A
  • Priority: Mar 12, 2014
    US US 201414207320 A
  • Priority: Mar 13, 2013
    US US 201361778814 P

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