{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"US_9498439_B2","frontPageModel":{"patentViewModel":{"ref":{"entityRefId":"181-207-353-757-992","entityRefType":"PATENT"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":8904,"type":"PATENT","title":"Univ Washington Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":15386,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8219,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search applicants and owners= \"Univ Washington', \"Washington Univ\", \"University of Washington\", \" Washington University\", \"Univ Washington NOT state\", \" Univ Washington NOT state NOT George\".
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Total patent: 10892
Search Applicants and Owners separately : \"wash* univ* st* lou*\"; \"univ* wash* lou*\"; \"Washington University St Louis\"; \"Wash* U* St Lo*\", \" Wash* U* in St Lo*\";
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Search applicants and owners= \"Univ Washington', \"Washington Univ\", \"University of Washington\", \" Washington University\", \"Univ Washington NOT state\", \" Univ Washington NOT state NOT George\".
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Total patent: 10892
Search Applicants and Owners separately : \"wash* univ* st* lou*\"; \"univ* wash* lou*\"; \"Washington University St Louis\"; \"Wash* U* St Lo*\", \" Wash* U* in St Lo*\";
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(a) the particle has an outer surface that is a membrane comprised of the at least one prodrug, and is further comprised of about 100 mol % to about 60 mol % phospholipid, and\n
(b) the prodrug comprises fumagillol or a derivative of fumagillol in which the spiro epoxide at C4 is ring opened to afford a tertiary alcohol and a ClCH2 group wherein the fumagillol or said derivative thereof is linked to an acyl moiety of a phosphoglyceride either directly or indirectly via a linker, wherein the linker is\n\nand the phosphoglyceride is attached at the amine, andwherein the fumagillol may be released from the phosphoglyceride backbone via enzyme cleavage."],"number":1,"annotation":false,"claim":true,"title":false},{"lines":["The composition of claim 1, wherein the outer surface of the particle is comprised of not more than 3 mol % of a prodrug."],"number":2,"annotation":false,"claim":true,"title":false},{"lines":["The composition of claim 1, wherein less than about 10% of the outer surface of the particle is cross-linked."],"number":3,"annotation":false,"claim":true,"title":false},{"lines":["The composition of claim 1, wherein the outer surface further comprises a homing ligand."],"number":4,"annotation":false,"claim":true,"title":false},{"lines":["The composition of claim 4, wherein the outer surface is not pegylated except for the homing ligand."],"number":5,"annotation":false,"claim":true,"title":false},{"lines":["The composition of claim 4, wherein the homing ligand is selected from the group consisting of antibodies, antibody fragments, peptides, asialoglycoproteins, polysaccharides, nucleic acids, small molecules, and peptidomimetics."],"number":6,"annotation":false,"claim":true,"title":false},{"lines":["The composition of claim 1, wherein the fumagillol is linked to an sn-2 acyl moiety of the phosphoglyceride."],"number":7,"annotation":false,"claim":true,"title":false},{"lines":["The composition of claim 7, wherein the sn-2 acyl moiety is at least 4 carbon atoms in length from the glycerol backbone sn-2 ester bond."],"number":8,"annotation":false,"claim":true,"title":false},{"lines":["The composition of claim 1, wherein the prodrug is"],"number":9,"annotation":false,"claim":true,"title":false},{"lines":["The composition of claim 1, wherein the phosphoglyceride of the prodrug is selected from the group consisting of phosphatidyl choline, phosphatidyl ethanolamine, phosphatidyl inositol, and phosphatidyl serine."],"number":10,"annotation":false,"claim":true,"title":false},{"lines":["The composition of claim 1, wherein the particle is between about 10 nm and 10 micrometers."],"number":11,"annotation":false,"claim":true,"title":false},{"lines":["The composition of claim 1, wherein the composition is formulated for intravenous administration."],"number":12,"annotation":false,"claim":true,"title":false},{"lines":["The composition of claim 4, wherein the homing ligand is selected from the group consisting of integrins αvβ3, α5β1, ICAM-1, VCAM-1 and VLA-4."],"number":13,"annotation":false,"claim":true,"title":false},{"lines":["The composition of claim 8, wherein the phosphoglyceride of the prodrug is selected from the group consisting of phosphatidyl choline, phosphatidyl ethanolamine, phosphatidyl inositol, and phosphatidyl serine."],"number":14,"annotation":false,"claim":true,"title":false},{"lines":["The composition of claim 10, wherein the phosphatidyl choline is 1-palmitoyl-2-(9′-oxo-nonanoyl)-sn-glycero-3-phosphocholine or 1-palmitoyl-2-azelaoyl-sn-glycero-3-phosphocholine."],"number":15,"annotation":false,"claim":true,"title":false},{"lines":["The composition of claim 1, wherein the outer surface of the particle is comprised of about 10 mol % of a prodrug."],"number":16,"annotation":false,"claim":true,"title":false},{"lines":["The composition of claim 1, wherein the particle is a micelle."],"number":17,"annotation":false,"claim":true,"title":false}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}