{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"US_9492400_B2","frontPageModel":{"patentViewModel":{"ref":{"entityRefType":"PATENT","entityRefId":"000-880-541-650-566"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":8635,"type":"PATENT","title":"MIT Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":30193,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8198,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Select Applicants and Owners= \"MIT\", \" Massachusetts Institute of Technology \", \"Massachus* Insti* Tech*\", \"Media Lab Massachus* Insti* Tech*\", \"Massachus* Tech* Inst*\".
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Select Applicants and Owners= \"MIT\", \" Massachusetts Institute of Technology \", \"Massachus* Insti* Tech*\", \"Media Lab Massachus* Insti* Tech*\", \"Massachus* Tech* Inst*\".
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(i) a plurality of nanoparticles having a diameter between about 10 nm and 1000 nm, the nanoparticles comprising\n\n(a) an amphiphilic block co-polymer core encapsulating an active agent,\n(b) a mucoadhesive coating comprising a material selected from the group consisting of lectins and positively charged polymers, the coating being present on the core and interacting through electrostatic interactions with the amphiphilic block co-polymer to form a coated nanoparticle, and\n(c) a targeting agent; and\n
(ii) a pharmaceutically acceptable carrier."],"number":1,"annotation":false,"title":false,"claim":true},{"lines":["The composition of claim 1, wherein the amphiphilic block co-polymer is functionalized with one or more groups selected from the group consisting of hydroxyl, amine, carboxy, maleimide, thiol, N-hydroxy-succinimide (NHS) esters, and azide groups."],"number":2,"annotation":false,"title":false,"claim":true},{"lines":["The composition of claim 2, wherein the amphiphilic block co-polymer is functionalized with carboxy groups."],"number":3,"annotation":false,"title":false,"claim":true},{"lines":["The composition of claim 1, wherein the targeting agent is disposed at a surface portion of the polymer core."],"number":4,"annotation":false,"title":false,"claim":true},{"lines":["The composition of claim 1, wherein the targeting agent is disposed on the surface portion of the polymer core and within the interior of the polymer core."],"number":5,"annotation":false,"title":false,"claim":true},{"lines":["The composition of claim 1, wherein the targeting agent is selected from the group consisting of nucleic acid aptamers, growth factors, hormones, cytokines, interleukins, antibodies, integrins, fibronectin receptors, p-glycoprotein receptors, and cell binding sequences."],"number":6,"annotation":false,"title":false,"claim":true},{"lines":["The composition of claim 1, providing controlled release of the active agent."],"number":7,"annotation":false,"title":false,"claim":true},{"lines":["The composition of claim 1, wherein the mucoadhesive coating is dislodged from the particle core at pH of about 7.4."],"number":8,"annotation":false,"title":false,"claim":true},{"lines":["The composition of claim 1, wherein the amphiphilic block co-polymer comprises a poly(alkylene glycol) block."],"number":9,"annotation":false,"title":false,"claim":true},{"lines":["The composition of claim 9, wherein the poly(alkylene glycol) is poly(ethylene glycol) or poly(propylene glycol)."],"number":10,"annotation":false,"title":false,"claim":true},{"lines":["The composition of claim 1, wherein the amphiphilic block co-polymer core comprises PEGylated poly(lactic acid)."],"number":11,"annotation":false,"title":false,"claim":true},{"lines":["The composition of claim 9, wherein the poly(alkylene glycol) is carboxylated."],"number":12,"annotation":false,"title":false,"claim":true},{"lines":["The composition of claim 9, wherein the poly(alkylene glycol) has a molecular weight between about 100 and about 7000 Daltons."],"number":13,"annotation":false,"title":false,"claim":true},{"lines":["The composition of claim 13, wherein the poly(alkylene glycol) has a molecular weight between about 100 and about 1000 Daltons."],"number":14,"annotation":false,"title":false,"claim":true},{"lines":["The composition of claim 13, wherein the poly(alkylene glycol) has a molecular weight between about 1000 and about 3500 Daltons."],"number":15,"annotation":false,"title":false,"claim":true},{"lines":["The composition of claim 13, wherein the poly(alkylene glycol) has a molecular weight between about 3500 and 7000 Daltons."],"number":16,"annotation":false,"title":false,"claim":true},{"lines":["The composition of claim 1, wherein the amphiphilic block co-polymer comprises a biodegradable polymer block."],"number":17,"annotation":false,"title":false,"claim":true},{"lines":["The composition of claim 17, wherein the biodegradable polymer block is selected from the group consisting of poly(arylates), poly(anhydrides), poly(hydroxy acids), polyesters, poly(ortho esters), polycarbonates, poly(propylene fumerates), poly(caprolactones), polyamides, polyphosphazenes, polyamino acids, polyethers, polyacetals, polylactides, polyhydroxyalkanoates, polyglycolides, polyketals, polyesteramides, poly(dioxanones), polyhydroxybutyrates, polyhydroxyvalyrates, polycarbonates, polyorthocarbonates, poly(vinyl pyrrolidone), biodegradable polycyanoacrylates, polyalkylene oxalates, polyalkylene succinates, poly(malic acid), poly(methyl vinyl ether), poly(ethylene imine), poly(acrylic acid), poly(maleic anhydride), biodegradable polyurethanes, polysaccharides, and mixtures of the above."],"number":18,"annotation":false,"title":false,"claim":true},{"lines":["The composition of claim 1, wherein the amphiphilic block co-polymer comprises a non-biodegradable polymer block selected from the group consisting of polystyrene, polyesters, non-biodegradable polyurethanes, polyureas, poly(vinyl alcohol), polyamides, poly(tetrafluoroethylene), poly(ethylene vinyl acetate), polypropylene, polyacrylate, non-biodegradable polycyanoacrylates, polymethacrylate, poly(methyl methacrylate), polyethylene, polypyrrole, polyanilines, polythiophene, poly(ethylene oxide), co-polymers of the above, and mixtures of the above."],"number":19,"annotation":false,"title":false,"claim":true},{"lines":["The composition of claim 1, wherein the material positively charged polymers are selected from the group consisting of chitosan, poly(lysine), poly(ethylene imine), and combinations thereof."],"number":20,"annotation":false,"title":false,"claim":true},{"lines":["The composition of claim 20, wherein the coating comprises chitosan, lectin, or both."],"number":21,"annotation":false,"title":false,"claim":true},{"lines":["The composition of claim 1, wherein the coating is a block co-polymer having a mucoadhesive block and a block that is adapted to participate in an interaction selected from the group consisting of electrostatic interactions, affinity interactions, metal coordination, physical adsorption, host-guest interactions, and hydrogen bonding interactions."],"number":22,"annotation":false,"title":false,"claim":true},{"lines":["The composition of claim 1, wherein the active agent is selected from the group consisting of a drug, vaccine, and polynucleotide."],"number":23,"annotation":false,"title":false,"claim":true},{"lines":["The composition of claim 23, wherein the active agent is a vaccine."],"number":24,"annotation":false,"title":false,"claim":true},{"lines":["The composition of claim 1, wherein the active agent is a protein."],"number":25,"annotation":false,"title":false,"claim":true},{"lines":["The composition of claim 25, wherein the active agent is insulin."],"number":26,"annotation":false,"title":false,"claim":true},{"lines":["A method for administering an active agent to an individual, comprising:\n
orally or nasally administering to the patient a composition comprising:\n\n(i) a plurality of nanoparticles having a size between about 10 nm and 1000 nm, the nanoparticles comprising\n(a) an amphiphilic block co-polymer core encapsulating active agent;\n(b) a mucoadhesive coating comprising a material selected from the group consisting of lectins and positively charged polymers, the coating present on the amphiphilic block co-polymer core and interacting through electrostatic interactions with the amphiphilic polymer to form a coated nanoparticle, and\n(c) a targeting agent; and\n
(ii) a pharmaceutically acceptable carrier."],"number":27,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 27, wherein the amphiphilic block co-polymer is functionalized with one or more groups selected from hydroxyl, amine, carboxy, maleimide, thiol, N-hydroxy-succinimide (NHS) esters, and azide groups."],"number":28,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 27, wherein the amphiphilic block co-polymer is functionalized with carboxy groups."],"number":29,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 27, wherein the targeting agent is disposed at a surface portion of the polymer core."],"number":30,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 27, wherein the targeting agent is disposed at a surface portion of the polymer core and within the interior portion of the polymer core."],"number":31,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 27, wherein the targeting agent is selected from the group consisting of nucleic acid aptamers, growth factors, hormones, cytokines, interleukins, antibodies, integrins, fibronectin receptors, p-glycoprotein receptors, and cell binding sequences."],"number":32,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 27, wherein the amphiphilic block co-polymer comprises a poly(alkylene glycol) block."],"number":33,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 33, wherein the poly(alkylene glycol) is poly(ethylene glycol) or poly(propylene glycol)."],"number":34,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 33, wherein the core comprises PEGylated poly(lactic acid)."],"number":35,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 33, wherein the poly(alkylene glycol) is carboxylated."],"number":36,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 33, wherein the poly(alkylene glycol) has a molecular weight between about 100 and about 7000 Daltons."],"number":37,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 33, wherein the poly(alkylene glycol) has a molecular weight between about 100 and about 1000 Daltons."],"number":38,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 33, wherein the poly(alkylene glycol) has a molecular weight between about 1000 and about 3500 Daltons."],"number":39,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 33, wherein the poly(alkylene glycol) has a molecular weight between about 3500 and 7000 Daltons."],"number":40,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 27, wherein the mucoadhesive coating is retained on the core though through electrostatic interactions."],"number":41,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 27, wherein the core comprises PEGylated poly(lactic acid)."],"number":42,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 27, wherein the polymer is a biodegradable polymer."],"number":43,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 43, wherein the biodegradable polymer is selected from the group consisting of poly(arylates), poly(anhydrides), poly(hydroxy acids), polyesters, poly(ortho esters), polycarbonates, poly(propylene fumerates), poly(caprolactones), polyamides, polyphosphazenes, polyamino acids, polyethers, polyacetals, polylactides, polyhydroxyalkanoates, polyglycolides, polyketals, polyesteramides, poly(dioxanones), polyhydroxybutyrates, polyhydroxyvalyrates, polycarbonates, polyorthocarbonates, poly(vinyl pyrrolidone), biodegradable polycyanoacrylates, polyalkylene oxalates, polyalkylene succinates, poly(malic acid), poly(methyl vinyl ether), poly(ethylene imine), poly(acrylic acid), poly(maleic anhydride), biodegradable polyurethanes, polysaccharides, co-polymers of the above, and mixtures of the above."],"number":44,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 27 comprising a non-biodegradable polymer selected from the group consisting of polystyrene, polyesters, non-biodegradable polyurethanes, polyureas, poly(vinyl alcohol), polyamides, poly(tetrafluoroethylene), poly(ethylene vinyl acetate), polypropylene, polyacrylate, non-biodegradable polycyanoacrylates, polymethacrylate, poly(methyl methacrylate), polyethylene, polypyrrole, polyanilines, polythiophene, poly(ethylene oxide), co-polymers of the above, and mixtures of the above."],"number":45,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 27, wherein the coating comprises lectin, chitosan, or both."],"number":46,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 27, wherein the coating is a block co-polymer having a mucoadhesive block and a block that is adapted to participate in an interaction selected from the group consisting of electrostatic interactions, affinity interactions, metal coordination, physical adsorption, host-guest interactions, and hydrogen bonding interactions."],"number":47,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 27, wherein the active agent is selected from the group consisting of a drug, vaccine, and polynucleotide."],"number":48,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 48, wherein the active agent is a vaccine."],"number":49,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 27, wherein the active agent is a protein."],"number":50,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 48, herein the active agent is insulin."],"number":51,"annotation":false,"title":false,"claim":true},{"lines":["The composition of claim 20, wherein the coating comprises a combination or a co-polymer of two materials selected from the group consisting of chitosan, poly(lysine), poly(ethylene imine), and lectin."],"number":52,"annotation":false,"title":false,"claim":true}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}