{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"US_9453069_B2","frontPageModel":{"patentViewModel":{"ref":{"entityRefId":"060-926-219-026-72X","entityRefType":"PATENT"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":8904,"type":"PATENT","title":"Univ Washington Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":15386,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8219,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search applicants and owners= \"Univ Washington', \"Washington Univ\", \"University of Washington\", \" Washington University\", \"Univ Washington NOT state\", \" Univ Washington NOT state NOT George\".
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Total patent: 10892
Search Applicants and Owners separately : \"wash* univ* st* lou*\"; \"univ* wash* lou*\"; \"Washington University St Louis\"; \"Wash* U* St Lo*\", \" Wash* U* in St Lo*\";
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Search applicants and owners= \"Univ Washington', \"Washington Univ\", \"University of Washington\", \" Washington University\", \"Univ Washington NOT state\", \" Univ Washington NOT state NOT George\".
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Total patent: 10892
Search Applicants and Owners separately : \"wash* univ* st* lou*\"; \"univ* wash* lou*\"; \"Washington University St Louis\"; \"Wash* U* St Lo*\", \" Wash* U* in St Lo*\";
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wherein:\n\nand a heavy chain variable region of the following sequence:\n(SEQ ID NO: 8)Xaa Val Gln Leu Val Glu Xaa Gly Gly Gly Leu Val Gln1 5 10 Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 15 20 25 Phe Thr Phe Ser Arg Tyr Ser Met Ser Trp Val Arg Gln 30 35 Ala Pro Gly Lys Gly Leu Xaa Leu Val Ala Gln Ile Asn40 45 50 Ser Val Gly Asn Ser Thr Tyr Tyr Pro Asp Xaa Val Lys 55 60 65 Gly Arg Phe Thr Ile Ser Arg Asp Asn Xaa Xaa Asn Thr 70 75 Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Xaa Asp Thr 80 85 90 Ala Val Tyr Tyr Cys Ala Ser Gly Asp Tyr Trp Gly Gln 95 100 Gly Thr Xaa Val Thr Val Ser Ser;105 110\nXaa at position 2 is Val or Ile;\nXaa at position 7 is Ser or Thr;\nXaa at position 14 is Thr or Ser;\nXaa at position 15 is Leu or Pro;\nXaa at position 30 is Ile or Val;\nXaa at position 50 is Arg, Gln, or Lys;\nXaa at position 88 is Val or Leu;\nXaa at position 105 is Gln or Gly;\nXaa at position 108 is Lys or Arg; and\nXaa at position 109 is Val or Leu;\n
wherein:\n\nwherein an elevated level of Aβ40 or Aβ42 as compared to a preselected control value identifies the subject as having preclinical or clinical Alzheimer's disease."],"number":1,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein the time interval is less than 1 week."],"number":2,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein the time interval is less than or equal to 24 hours."],"number":3,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein the time interval is less than or equal to 3 hours."],"number":4,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein the subject is human and the diagnostic antibody is a humanized antibody or an epitope-binding fragment thereof."],"number":5,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 5, wherein the diagnostic antibody has a light chain variable region of the sequence given by SEQ ID NO:9 and a heavy chain variable region of the sequence given by SEQ ID NO:10."],"number":6,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 5, wherein the humanized antibody or epitope-binding fragment thereof comprises a light chain of the sequence given by SEQ ID NO:11 and a heavy chain of the sequence given by SEQ ID NO:12."],"number":7,"annotation":false,"claim":true,"title":false}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}Xaa at position 1 is Glu or Gln;\nXaa at position 7 is Ser or Leu;\nXaa at position 46 is Glu, Val, Asp, or Ser;\nXaa at position 63 is Thr or Ser;\nXaa at position 75 is Ala, Ser, Val, or Thr;\nXaa at position 76 is Lys or Arg;\nXaa at position 89 is Glu or Asp; and\nXaa at position 107 is Leu or Thr;\n