Method And Compositions For Treatment Of Calcineurin-related Diseases

Abstract

Therapeutic compositions for treatment of protein serine/threonine phosphatase-related diseases are obtained by engineering amino acid sequences that disrupt interaction between the protein serine/threonine phosphatase and a protein inhibitor and are provided herein. Calcineurin and PPI are examples of protein serine/threonine phosphatases. RCAN1 is an inhibitor of calcineurin and is overexpressed in patients with serious diseases, such as Down syndrome and Alzheimer's disease. Molecules that bind RCAN1 at regions that interact with calcineurin selectively modulate functions of calcineurin to treat these diseases. Methods of treating a subject for a protein serine/threonine phosphatase-related disease by administering a molecule having an amino acid sequence selected from the group of SEQ ID NOs: 1-19 are further provided.


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Document History
  • Publication: Sep 27, 2016
  • Application: Aug 6, 2015
    US US 201514819623 A
  • Priority: Aug 6, 2015
    US US 201514819623 A
  • Priority: Aug 6, 2014
    US US 201462033766 P

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