Pactamycin Analogs And Methods Of Making Thereof

Abstract

This disclosure describes the molecular cloning of a pactamycin biosynthetic gene cluster from Streptomyces pactum ATCC 27456, characterization of individual genes in the gene cluster and the proteins encoded thereby as well as uses thereof. The pactamycin gene cluster is located within an 86.35 kilobases genetic locus and includes 53 open reading frames, 26 of which are considered to be the core cluster directly involved in the biosynthesis of pactamycin. The present disclosure also relates to the use of the pactamycin biosynthetic genes located within the identified gene cluster for drug design and development purposes, including the development of pactamycin analogs that are more efficacious and less toxic. Also provided are drugs and antibiotics so produced, as well as methods of their use.


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Document History
  • Publication: Sep 27, 2016
  • Application: Jan 6, 2015
    US US 201514590677 A
  • Priority: Jan 6, 2015
    US US 201514590677 A
  • Priority: Oct 16, 2009
    US US 59642909 A
  • Priority: Apr 18, 2008
    US US 2008/0060876 W
  • Priority: Apr 19, 2007
    US US 91282407 P

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