{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"US_9365508_B2","frontPageModel":{"patentViewModel":{"ref":{"entityRefId":"083-356-952-357-399","entityRefType":"PATENT"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":11807,"type":"PATENT","title":"The University of Dundee Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":2439,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8437,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search Applicants and Owners separately: uni* dundee. Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 2316
Search Applicants and Owners separately:Univ* Andrews. Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 1345
Search Applicants and Owners separately: uni* dundee. Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 2316
Search Applicants and Owners separately:Univ* Andrews. Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 1345
wherein:\n
X is O and Y is S;\n
—Z— is —C(O)—;\n
Ar is 1,4-phenylene;\n
each of —R1 and —R2 is —H, and —R3 is an amino-substituted, saturated, straight chain C3-C10 alkyl group; and\n
Ar′— is a moiety of formula (II)\n\n
wherein:\n
each T1, T2, and T3 is a carbon atom, where each R6 is independently selected from the group consisting of hydrogen, O1-6 alkyl, halo, C1-6 alkoxy, alkylthio, alkylamino and dialkylamino;\n
each R7 is independently selected from the group consisting of hydrogen, halo, nitro, cyano, carboxy, formyl or C(═O)OR4, C(═S)OR4, C(═O)SR4, C(═S)SR4, C(═O)NH2 and C(═S)NH2 w herein (i) one or both hydrogen atoms of C(═O)NH2 and C(═S)NH2 may be independently exchanged for R4, C(O)R4, S(O)R4, S(O)2R4 and SO2OR4, and (ii) at least one R7 is not hydrogen; and\n
R8 is selected from the group consisting of alkyl, alkoxy, alkylthio, OH, SH, halo, NHC(═O)R4, NHC(═S)R4 or NH2 wherein one or both hydrogen atoms of the NH2 may be independently exchanged for R4, OC(═O)R4, OC(═S)R4, SC(═O)R4, or SC(═S)R4,\n
each R4 is independently selected from the group consisting of alkyl and aryl,\n
or a physiologically acceptable salt or solvate thereof."],"number":1,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 1, or a physiologically acceptable salt or solvate thereof, wherein R8 is a branched alkyl group."],"number":2,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 1, or a physiologically acceptable salt or solvate thereof, wherein R8 is an alkyl group."],"number":3,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 1, or a physiologically acceptable salt or solvate thereof, wherein R8 is selected from the group consisting of alkyl, alkoxy, and NH2 wherein one or both hydrogen atoms of the NH2 may be independently exchanged for alkyl."],"number":4,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 1, or a physiologically acceptable salt or solvate thereof, wherein both R6s are hydrogen."],"number":5,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 1, or a physiologically acceptable salt or solvate thereof, wherein neither R7 is hydrogen."],"number":6,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 6, or a physiologically acceptable salt or solvate thereof, wherein each R7 is halo."],"number":7,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 1, or a physiologically acceptable salt or solvate thereof, wherein R3 is substituted with one or more amino groups."],"number":8,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 8, or a physiologically acceptable salt or solvate thereof, wherein R3 is substituted once at its end distal to Z."],"number":9,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 8, or a physiologically acceptable salt or solvate thereof, wherein the amino group is morpholino."],"number":10,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 8, or a physiologically acceptable salt or solvate thereof, wherein the amino group is quaternized."],"number":11,"annotation":false,"claim":true,"title":false},{"lines":["A pharmaceutical composition comprising a compound as defined in claim 1, or a physiologically acceptable salt or solvate thereof, together with a pharmaceutically acceptable carrier."],"number":12,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 1, wherein the compound is 5-dimethylamino-pentanoic acid {4-[3-(4-butoxy-3,5-dichloro-benzoyl)-thioureido]-phenyl}-amide."],"number":13,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 1, wherein the compound is 5-dimethylamino-pentanoic acid {4-[3-(4-butoxy-3,5-dichloro-benzoyl)-thioureido]-phenyl}-amide hydrochloride."],"number":14,"annotation":false,"claim":true,"title":false}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}