{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"US_9359299_B2","frontPageModel":{"patentViewModel":{"ref":{"entityRefId":"054-708-379-402-242","entityRefType":"PATENT"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":10802,"type":"PATENT","title":"Brown University - Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":4664,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8267,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search Applicants and Owners separately: \"Brown Univ*\"
Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 2360
Search Applicants and Owners separately:Georgetown Univ*. Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 3015
Search Applicants and Owners separately: \"Brown Univ*\"
Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 2360
Search Applicants and Owners separately:Georgetown Univ*. Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 3015
L is —C(═O)NH—, —NHC(═O)—, —C(═O)O—, —C(═O)—CH2—,\n\n
R1, R2, R3, R4, R6, R7, R8, R9, and R10 are each independently selected from hydrogen, halogen, hydroxyl, cyano, nitro, trifluoromethyl, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted amino, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted alkoxyl, substituted or unsubstituted aryloxyl, substituted or unsubstituted carbonyl, or substituted or unsubstituted carboxyl; and\n
X is substituted or unsubstituted heteroaryl,\n\nor a pharmaceutically acceptable salt or prodrug thereof, wherein:\n
L is —C(═O)NH—, —NHC(═O)—, —C(═O)O—, —C(═O)—CH2—,\n\n
R1, R2, R3, R4, R6, R7, R8, R9, and R10 are each independently selected from hydrogen, halogen, hydroxyl, cyano, nitro, trifluoromethyl, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted amino, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted alkoxyl, substituted or unsubstituted aryloxyl, substituted or unsubstituted carbonyl, or substituted or unsubstituted carboxyl; and\n
X is substituted or unsubstituted heteroaryl,\n\nor a pharmaceutically acceptable salt or prodrug thereof, wherein:\n
A is S or NH;\n
L is —C(═O)NH—, —NHC(═O)—, —C(═O)O—, —C(═O)—CH2—,\n\n
R1, R2, R3, R4, R6, R7, R8, R9, and R10 are each independently selected from hydrogen, halogen, hydroxyl, cyano, nitro, trifluoromethyl, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted amino, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted alkoxyl, substituted or unsubstituted aryloxyl, substituted or unsubstituted carbonyl, or substituted or unsubstituted carboxyl;\n
X1 and X2 are each independently selected from hydrogen, halogen, trifluoromethyl, substituted or unsubstituted alkyl, or substituted or unsubstituted heteroaryl; and\n
Z is S or NH,\n
wherein one of X1 or X2 is substituted or unsubstituted heteroaryl,\n\nor a pharmaceutically acceptable salt or prodrug thereof, wherein:\n
L is —C(═O)NH—, —NHC(═O)—, —C(═O)O—, —C(═O)—CH2—,\n\n
R1, R2, R3, R4, R6, R7, R8, R9, and R10 are each independently selected from hydrogen, halogen, hydroxyl, cyano, nitro, trifluoromethyl, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted amino, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted alkoxyl, substituted or unsubstituted aryloxyl, substituted or unsubstituted carbonyl, or substituted or unsubstituted carboxyl; and\n
X is substituted or unsubstituted heteroaryl, and\n\nor a pharmaceutically acceptable salt or prodrug thereof, wherein:\n
L is —C(═O)NH—, —NHC(═O)—, —C(═O)O—, —C(═O)—CH2—,\n\n
R1, R2, R3, R4, R6, R7, R8, R9, and R10 are each independently selected from hydrogen, halogen, hydroxyl, cyano, nitro, trifluoromethyl, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted amino, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted alkoxyl, substituted or unsubstituted aryloxyl, substituted or unsubstituted carbonyl, or substituted or unsubstituted carboxyl; and\n
X is substituted or unsubstituted heteroaryl."],"number":1,"annotation":false,"claim":true,"title":false},{"lines":["A compound of the following structure:\nor a pharmaceutically acceptable salt or prodrug thereof, wherein:\n
L is —C(═O)NH—, —NHC(═O)—, —C(═O)O—, —C(═O)—CH2—,\n\n
R1, R2, R3, and R4 are each independently selected from hydrogen, halogen, hydroxyl, cyano, nitro, trifluoromethyl, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted amino, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted alkoxyl, substituted or unsubstituted aryloxyl, substituted or unsubstituted carbonyl, or substituted or unsubstituted carboxyl;\n
R5 is substituted or unsubstituted aryl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted alkynyl, or dansyl; and\n
X is substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted sulfonyl, or substituted or unsubstituted alkynyl,\n
wherein if L is —C(═O)NH—, R5 is unsubstituted phenyl, and R1, R2, R3, and R4 are each hydrogen, then X is not"],"number":2,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 2, wherein R5 is substituted or unsubstituted phenyl."],"number":3,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 3, wherein R5 is fluoro-substituted phenyl."],"number":4,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 2, wherein X is pyridyl."],"number":5,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 2, wherein X is phenyl, cyclohexyl, alkynyl, or dansyl."],"number":6,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 2, wherein L is —C(═O)NH—."],"number":7,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 1, wherein the compound has the following structure:\nor a pharmaceutically acceptable salt or prodrug thereof, wherein:\n
L is —C(═O)NH—, —NHC(═O)—, —C(═O)O—, —C(═O)—CH2—,\n\n
R1, R2, R3, R4, R6, R7, R8, R9, and R10 are each independently selected from hydrogen, halogen, hydroxyl, cyano, nitro, trifluoromethyl, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted amino, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted alkoxyl, substituted or unsubstituted aryloxyl, substituted or unsubstituted carbonyl, or substituted or unsubstituted carboxyl; and\n
X is substituted or unsubstituted heteroaryl."],"number":8,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 1, wherein the compound has the following structure:\nor a pharmaceutically acceptable salt or prodrug thereof, wherein:\n
L is —C(═O)NH—, —NHC(═O)—, —C(═O)O—, —C(═O)—CH2—,\n\n
R1, R2, R3, R4, R6, R7, R8, R9, and R10 are each independently selected from hydrogen, halogen, hydroxyl, cyano, nitro, trifluoromethyl, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted amino, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted alkoxyl, substituted or unsubstituted aryloxyl, substituted or unsubstituted carbonyl, or substituted or unsubstituted carboxyl; and\n
X is substituted or unsubstituted heteroaryl."],"number":9,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 1, wherein the compound has the following structure:\nor a pharmaceutically acceptable salt or prodrug thereof, wherein:\n
A is S or NH;\n
L is —C(═O)NH—, —NHC(═O)—, —C(═O)O—, —C(═O)—CH2—,\n\n
R1, R2, R3, R4, R6, R7, R8, R9, and R10 are each independently selected from hydrogen, halogen, hydroxyl, cyano, nitro, trifluoromethyl, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted amino, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted alkoxyl, substituted or unsubstituted aryloxyl, substituted or unsubstituted carbonyl, or substituted or unsubstituted carboxyl;\n
X1 and X2 are each independently selected from hydrogen, halogen, trifluoromethyl, substituted or unsubstituted alkyl, or substituted or unsubstituted heteroaryl; and\n
Z is S or NH,\n
wherein one of X1 or X2 is substituted or unsubstituted heteroaryl."],"number":10,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 1, wherein the compound has the following structure:\nor a pharmaceutically acceptable salt or prodrug thereof, wherein:\n
L is —C(═O)NH—, —NHC(═O)—, —C(═O)O—, —C(═O)—CH2—,\n\n
R1, R2, R3, R4, R6, R7, R8, R9, and R10 are each independently selected from hydrogen, halogen, hydroxyl, cyano, nitro, trifluoromethyl, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted amino, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted alkoxyl, substituted or unsubstituted aryloxyl, substituted or unsubstituted carbonyl, or substituted or unsubstituted carboxyl; and\n
X is substituted or unsubstituted heteroaryl."],"number":11,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 1, wherein the compound has the following structure:\n
or a pharmaceutically acceptable salt or prodrug thereof, wherein:\n
L is —C(═O)NH—, —NHC(═O)—, —C(═O)O—, —C(═O)—CH2—,\n\n
R1, R2, R3, R4, R6, R7, R8, R9, and R10 are each independently selected from hydrogen, halogen, hydroxyl, cyano, nitro, trifluoromethyl, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted amino, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted alkoxyl, substituted or unsubstituted aryloxyl, substituted or unsubstituted carbonyl, or substituted or unsubstituted carboxyl; and\n
X is substituted or unsubstituted heteroaryl."],"number":12,"annotation":false,"claim":true,"title":false},{"lines":["A compound of the following structure:\nor a pharmaceutically acceptable salt or prodrug thereof, wherein:\n
X is substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted sulfonyl, substituted or unsubstituted alkynyl, or absent; and\n
Y is substituted or unsubstituted thiazole, substituted or unsubstituted triazole, substituted or unsubstituted imidazole, or —V—CH2—O—, wherein V is substituted or unsubstituted cyclohexyl, alkynyl, or substituted or unsubstituted pyridyl."],"number":13,"annotation":false,"claim":true,"title":false},{"lines":["A compound of the following structure:\nor a pharmaceutically acceptable salt or prodrug thereof, wherein:\n
n is 0, 1, or 2; and\n
R6, R7, R8, and R9 are each independently selected from hydrogen, halogen, hydroxyl, cyano, nitro, trifluoromethyl, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted amino, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted alkoxyl, substituted or unsubstituted aryloxyl, substituted or unsubstituted carbonyl, or substituted or unsubstituted carboxyl."],"number":14,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 2, wherein the compound is selected from the group consisting of:\n\n\nwherein R6, R7, R8, R9, and R10 are each independently selected from hydrogen, chloro, fluoro, trifluoromethyl, hydroxyl, methoxyl, and methyl and wherein R6, R7, R8, R9, and R10 are not simultaneously hydrogen,\nwherein X is phenyl, cyclohexyl, alkynyl, dansyl, or pyridyl, and\nwherein R5 is phenyl, cyclohexyl, alkynyl, dansyl, or pyridyl,\n
or a pharmaceutically acceptable salt or prodrug thereof."],"number":15,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 14, wherein the compound is selected from the group consisting of:\n
or a pharmaceutically acceptable salt or prodrug thereof."],"number":16,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 13, wherein the compound is selected from the group consisting of:\n
or a pharmaceutically acceptable salt or prodrug thereof,\n"],"number":17,"annotation":false,"claim":true,"title":false},{"lines":["A composition comprising one or more compounds of claim 1 and a pharmaceutically acceptable carrier."],"number":18,"annotation":false,"claim":true,"title":false},{"lines":["A method of treating breast cancer in a subject, comprising:\nwherein W is cyclohexyl, alkynyl, or pyridyl.\n
administering to the subject an effective amount of a compound selected from the group consisting of:\n\nor a pharmaceutically acceptable salt or prodrug thereof\n
and a pharmaceutically acceptable carrier."],"number":19,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 19, wherein the cancer is breast cancer."],"number":20,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 20, wherein the breast cancer is endocrine resistant breast cancer."],"number":21,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 19, further comprising administering a second therapeutic agent to the subject."],"number":22,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 22, wherein the second therapeutic agent is an antiestrogen or an aromatase inhibitor."],"number":23,"annotation":false,"claim":true,"title":false},{"lines":["A method of treating a subject with anti-estrogen resistant breast cancer, comprising:\n
1) selecting a subject with anti-estrogen resistant breast cancer;\n
2) administering to the subject one or more of the compounds of the following structure:\n\nor a pharmaceutically acceptable salt or prodrug thereof, wherein:\n
L is —C(═O)NH—, —NHC(═O)—, —C(═O)O—, —C(═O)—CH2—,\n\n
R1, R2, R3, and R4 are each independently selected from hydrogen, halogen, hydroxyl, cyano, nitro, trifluoromethyl, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted amino, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted alkoxyl, substituted or unsubstituted aryloxyl, substituted or unsubstituted carbonyl, or substituted or unsubstituted carboxyl;\n
R5 is substituted or unsubstituted aryl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted alkynyl, or dansyl; and\n
X is substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted sulfonyl, or substituted or unsubstituted alkynyl; and\n
3) administering to the subject an anti-estrogen compound."],"number":24,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 2, wherein R1, R2, R3, and R4 are each hydrogen; R5 is substituted or unsubstituted phenyl, L is —C(═O)NH—, and X is phenyl or pyridyl."],"number":25,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 2, wherein R1, R2, R3, and R4 are each hydrogen; R5 is unsubstituted phenyl, L is —C(═O)NH—, and X is unsubstituted phenyl."],"number":26,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 2, wherein R1, R2, R3, and R4 are each hydrogen; R5 is substituted phenyl, L is —C(═O)NH—, and X is pyridyl."],"number":27,"annotation":false,"claim":true,"title":false}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}