Haemophilus Influenzae Type Iv Pili

Abstract

The invention described herein relates to a Haemophilus influenzae (H. influenzae) regulon encoding type IV pili. In particular, the invention relates to type IV pili from nontypeable H. influenzae (NTHi) and from H. influenzae strains a, b, c, e and f. The invention provides isolated H. influenzae pilus polynucleotides and polypeptides encoded by the polynucleotides as well as polynucleotides and polypeptides encoded by the polynucleotides involved in the assembly/disassembly of the structure. The invention also relates to uses of these polynucleotides and/or polypeptides including methods for eliciting an immune response to H. influenzae and methods of treating and preventing H. influenzae related pathological conditions.


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Document History
  • Publication: Apr 12, 2016
  • Application: Jan 9, 2015
    US US 201514593401 A
  • Priority: Jan 9, 2015
    US US 201514593401 A
  • Priority: Feb 13, 2013
    US US 201313766008 A
  • Priority: Jan 12, 2011
    US US 201113005166 A
  • Priority: Jan 7, 2008
    US US 97027308 A
  • Priority: Dec 21, 2004
    US US 1900504 A
  • Priority: Dec 23, 2003
    US US 53229603 P

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