Method Of Producing T Cell Receptor-deficient T Cells Expressing A Chimeric Receptor

Abstract

The invention is directed to modified T cells, methods of making and using isolated, modified T cells, and methods of using these isolated, modified T cells to address diseases and disorders. In one embodiment, this invention broadly relates to TCR-deficient T cells, isolated populations thereof, and compositions comprising the same. In another embodiment of the invention, these TCR-deficient T cells are designed to express a functional non-TCR receptor. The invention also pertains to methods of making said TCR-deficient T cells, and methods of reducing or ameliorating, or preventing or treating, diseases and disorders using said TCR-deficient T cells, populations thereof, or compositions comprising the same.


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Document History
  • Publication: Mar 1, 2016
  • Application: Apr 30, 2012
    US US 201213459664 A
  • Priority: Apr 30, 2012
    US US 201213459664 A
  • Priority: Oct 29, 2010
    US US 201013502978 A
  • Priority: Oct 29, 2010
    US US 2010/0054846 W
  • Priority: Oct 29, 2009
    US US 25598009 P

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