{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"US_9243278_B2","frontPageModel":{"patentViewModel":{"ref":{"entityRefType":"PATENT","entityRefId":"101-834-045-190-120"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":10802,"type":"PATENT","title":"Brown University - Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":4664,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8267,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search Applicants and Owners separately: \"Brown Univ*\"
Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 2360
Search Applicants and Owners separately: \"Brown Univ*\"
Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 2360
a) labeling at least two types of cells with distinct intracellular fluorescent marker labels;\n
b) seeding a cell culture medium with the at least two types of cells in a suspension;\n
c) combining a drug candidate with the cells in suspension, and then culturing the cells in a non-adherent mold to thereby form spheroids, or culturing the cells in the non-adherent mold to form spheroids and then combining the spheroids with the drug candidate, or culturing the cells in the non-adherent mold to form spheroids while combining the cells with the drug candidate; and\n
d) comparing the distribution of the at least two different types of cells to that of spheroids of essentially the same cell suspension cultured in the absence of the drug candidate."],"number":1,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein at least one of the types of cells is a connective tissue cell."],"number":2,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 2, wherein the connective tissue is a fibroblast cell."],"number":3,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 2, wherein the connective tissue is a myofibroblast cell."],"number":4,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein at least one of the types of cells is a parenchymal cell."],"number":5,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 5, wherein the parenchymal cell is at least one member selected from the group consisting of an epithelial cell, a muscle cell, a neural cell, kidney cells, lung cells, cardiomyocyte cells and liver cells."],"number":6,"annotation":false,"title":false,"claim":true}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}