{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"US_9199918_B2","frontPageModel":{"patentViewModel":{"ref":{"entityRefId":"184-888-498-494-623","entityRefType":"PATENT"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":11916,"type":"PATENT","title":"Georgetown University Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":3191,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8504,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search Applicants and Owners separately:Georgetown Univ*. Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 3015
Search Applicants and Owners separately:Georgetown Univ*. Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 3015
administering to the subject an effective amount of one or more compounds of the following structure:\n\nor a pharmaceutically acceptable salt thereof, wherein:\n
Ar is\n\nwherein R is trifluoromethyl, chloro, fluoro, methoxy, amino, or nitro;\n
L is absent;\n
R1, R4, and R5 are each independently selected from the group consisting of hydrogen, halogen, hydroxyl, cyano, nitro, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted amino, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted alkoxyl, substituted or unsubstituted aryloxyl, substituted or unsubstituted carbonyl, and substituted or unsubstituted carboxyl; and\n
R2 and R3 are each independently selected from the group consisting of hydrogen, halogen, hydroxyl, cyano, nitro, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted amino, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted alkoxyl, substituted or unsubstituted aryloxyl, substituted or unsubstituted carbonyl, or substituted or unsubstituted carboxyl, or R2 and R3 combine to form a substituted or unsubstituted heterocycloalkyl,\n
or a composition comprising the compound and a pharmaceutically acceptable carrier."],"number":1,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, further comprising administering a second therapeutic agent to the subject."],"number":2,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 2, wherein the second therapeutic agent is a chemotherapeutic agent."],"number":3,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein R2 and R3 combine to form a substituted or unsubstituted heterocycloalkyl."],"number":4,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein Ar is\n
wherein R is trifluoromethyl, chloro, fluoro, methoxy, amino, or nitro."],"number":5,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein the compound is"],"number":6,"annotation":false,"claim":true,"title":false}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}