{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"US_9186405_B2","frontPageModel":{"patentViewModel":{"ref":{"entityRefType":"PATENT","entityRefId":"142-652-674-021-266"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":8880,"type":"PATENT","title":"Univ Toronto Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":3464,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8213,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search Applicants and Owners separately = \"Univ Toronto\", \"Toronto Univ\", \"University of Toronto\", \"Toronto University\". \"Univ Toron* Innovat*\" , \"Univ* Toron*\".
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Total patents: 3039
Search Applicants and Owners separately: \"McGill univ*\";
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Search Applicants and Owners separately = \"Univ Toronto\", \"Toronto Univ\", \"University of Toronto\", \"Toronto University\". \"Univ Toron* Innovat*\" , \"Univ* Toron*\".
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Total patents: 3039
Search Applicants and Owners separately: \"McGill univ*\";
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obtaining a bodily fluid sample from a subject;\n
isolating microvesicles captured from the bodily fluid sample using Annexin V;\n
detecting the presence of EGFRvIII in the microvesicles, wherein the EGFRvIII in the microvesicle is capable of inducing cellular transformation; and\n
determining the presence or aggressiveness of a cancer based on the presence of the EGFRvIII in the microvesicles in the bodily fluid sample."],"number":1,"annotation":false,"title":false,"claim":true},{"lines":["The method according to claim 1, wherein the presence of the EGFRvIII in the microvesicles is detected by immunoblot, immunoprecipitation, ELISA, RIA, or flow cytometry."],"number":2,"annotation":false,"title":false,"claim":true},{"lines":["The method according to claim 1, wherein the EGFRvIII in the microvesicles is detected by ELISA with wells coated with Annexin V."],"number":3,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the bodily fluid sample is selected from the group consisting of blood, urine, cerebrospinal fluid, ascites, saliva, lavage, semen, glandular secretions, exudate and feces."],"number":4,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 4, wherein the blood sample is serum or plasma."],"number":5,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the cancer is a brain tumor."],"number":6,"annotation":false,"title":false,"claim":true},{"lines":["A method of determining the presence or aggressiveness of a tumor in a subject suspected or at risk of having cancer, the method comprising:\n
obtaining blood, plasma or serum from the subject suspected or at risk of having cancer;\n
isolating microvesicles captured from the blood, plasma, or serum using Annexin V;\n
measuring with immunoblot, immunoprecipitation, ELISA, RIA, flow cytometry, electron microscopy or mass spectrometry the presence of EGFRvIII in the microvesicles, wherein the EGFRvIII is capable of inducing cellular transformation, in the blood, plasma, or serum obtained from the subject; and\n
determining the presence or aggressiveness of a tumor based on the presence of the EGFRvIII in the blood, plasma or serum."],"number":7,"annotation":false,"title":false,"claim":true}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}