Methods For Treating Neural Cell Swelling

Abstract

A composition comprising a novel Ca2+-activated, [ATP]i-sensitive nonspecific cation (NCCa-ATP) channel is described. The channel is found in mammalian neural cells and exhibits a different sensitivity to block by various adenine nucleotides, and is activated by submicromolar [Ca]i. The NCCa-ATP channel is activated under conditions of ATP depletion, which causes severe cell depolarization, followed by cell swelling. The NCCa-ATP channel is regulated by a sulfonylurea receptor and is inhibited by sulfonylurea compounds glibenclamide and tolbutamide. Methods employing compositions comprising the NCCa-ATP channel to screen for compounds that block the channel and the use of such antagonists as therapeutics in preventing brain swelling and damage are described. In addition, methods employing compositions comprising the Kir2.3 channel to screen for compounds that open the channel and the use of such antagonists as therapeutics in preventing brain swelling and damage are described.


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Document History
  • Publication: Aug 18, 2015
  • Application: Feb 20, 2014
    US US 201414184947 A
  • Priority: Feb 20, 2014
    US US 201414184947 A
  • Priority: May 30, 2012
    US US 201213483824 A
  • Priority: Sep 19, 2007
    US US 85754707 A
  • Priority: Apr 5, 2005
    US US 9933205 A
  • Priority: Mar 20, 2003
    US US 39156103 A
  • Priority: Mar 20, 2002
    US US 36593302 P

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