{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"US_8957251_B2","frontPageModel":{"patentViewModel":{"ref":{"entityRefId":"023-365-104-891-191","entityRefType":"PATENT"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":11699,"type":"PATENT","title":"Oregon State University - Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":2728,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8353,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search Applicants and Owners separately: oregon state uni*
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wherein R1 is H or OH; and\n
R2 is H or —C(O)R4 wherein R4 is lower aliphatic or aromatic;\n
R3 represents —C(O)R5—C(O)OR6; or —C(O)NR7R8 and R5, R6, R7 and R8 independently are H, lower aliphatic, aryl or aralkyl."],"number":1,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 1, wherein R4 is an aromatic moiety."],"number":2,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 1, wherein R3 is an amino acid."],"number":3,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 3, wherein R3 is an aromatic amino acid."],"number":4,"annotation":false,"claim":true,"title":false},{"lines":["A method for making the compound of the formula\nwhere R1 is H or OH, comprising:\n
transforming a host cell with one or more expression vectors comprising an isolated nucleic acid molecule encoding a protein consisting of SEQ ID Nos.: 1 to 53; and\n
culturing the host cell in a culture medium to produce the compound of the following formula\n\n
where R1 is H or OH."],"number":5,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 5, further comprising modifying the compound of formula\nto produce a compound of the formula\nwhere R3 is a protecting group."],"number":6,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 5, further comprising modifying the compound of formula\nto produce a pactamycin analog of the formula\nwhere R2 is an alkyl, acyl or aryl group."],"number":7,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 7, wherein the pactamycin analog has the formula\n
R4 is selected from\n\n
X is selected from H, lower alkyl, —OR9, halogen, —NO2, —NR10R11;\n
Y is H, halogen or lower alkyl; and\n
R9, R10 and R11 independently are selected from H, lower alkyl and acyl."],"number":8,"annotation":false,"claim":true,"title":false},{"lines":["A pactamycin analog of the formula\n
R2 is H or —C(O)R4 wherein R4 is lower aliphatic or aromatic;\n
R3 represents —C(O)R5—C(O)0R6; or —C(O)NR7R8 and R5, R6, R7 and R8 independently are H, lower aliphatic, aryl or aralkyl."],"number":9,"annotation":false,"claim":true,"title":false},{"lines":["The pactamycin analog of claim 9, wherein R3 is an amino acid."],"number":10,"annotation":false,"claim":true,"title":false}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}